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1.
Investig. desar. ; 29(1): 41-68, ene.-jun. 2021. tab
Artigo em Espanhol | LILACS, COLNAL | ID: biblio-1346388

RESUMO

RESUMEN La interacción de las instituciones públicas con la comunidad y demás actores sociales es una práctica que se está transformando mundialmente debido al reconocimiento de la ciudadanía como actor fundamental en la toma de decisiones sobre asuntos públicos y a la incorporación de plataformas digitales en su gestión. La perspectiva de la comunicación pública sostiene que más allá de difundir información, las instituciones del gobierno deben propiciar prácticas de participación, diálogo y debate por parte de los ciudadanos para alcanzar la transformación social. En este contexto, la investigación que se presenta a continuación corresponde a un estudio de caso múltiple que se propuso analizar, desde una perspectiva principalmente cualitativa, las publicaciones digitales de seis gobernaciones colombianas realizadas entre octubre y noviembre de 2019, para caracterizar sus prácticas de comunicación y determinar si llevan a cabo procesos de comunicación pública.


ABSTRACT The interaction of public institutions with the community and other social actors is a practice that is being transformed worldwide due to the recognition of citizens as fundamental actors in decision-making on public affairs, and the incorporation of digital platforms in their management. The public communication perspective argues that beyond disseminating information, government institutions should promote practices of participation, dialogue and debate by citizens to achieve social transformation. In this context, the research presented below corresponds to a Multiple Case Study that set out to analyze, from a mainly qualitative perspective, the digital publications of six Colombian governorships, carried out between October and November 2019, to characterize their communication practices and determine whether they carry out public communication processes.


Assuntos
Humanos , Ecossistema , Comunicação , Participação da Comunidade , Internet , Rede Social , Governo
3.
Rev. méd. Chile ; 147(12): 1553-1560, dic. 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1094189

RESUMO

ABSTRACT Background Prognosis of patients with Diffuse Large B Cell Lymphoma (DLBCL) is highly variable, and despite the use of modern immunochemotherapy regimens, almost 50% of patients will eventually relapse. Standard risk models, like the International Prognostic Index or the Revised International Prognostic Index (R_IPI) incorporate patient and tumor characteristics but do not consider variables related to host adaptive immunity which have been shown to be of significant prognostic value in non-Hodgkin lymphomas. Aim To analyze the prognostic significance of the absolute monocyte count at diagnosis in diffuse large-B-cell lymphoma in a retrospective setting. Material and Methods We reviewed data of 171 patients with DLBCL treated with Rituximab-based immunochemotherapy at two reference public Hospitals in Montevideo-Uruguay. The outcome measures were overall and relapse free survival. Results The absolute monocyte count, analyzed as a dichotomized variable predicted progression-free and overall survival in low risk patients according to the R-IPI score. Worse outcomes were observed in those with high monocyte count al diagnosis. Conclusions Absolute monocyte count could help in the identification of high-risk patients otherwise expected to have a good prognosis according to traditional scores.


Antecedentes El pronóstico de pacientes con Linfoma Difuso de Células B Grandes (DLBCL) es muy variable y el 50% de los pacientes recae a pesar de uso de regímenes actualizados de inmuno-quimioterapia. Los modelos pronósticos clásicos como el International Prognostic Index o el Revised International Prognostic Index (R_IPI) incorporan características del paciente o del tumor pero no incorporan variables asociadas a la inmunidad adaptativa que tienen valor en linfomas no Hodgkin. Objetivo Analizar retrospectivamente el valor pronóstico del recuento absoluto de monocitos al momento del diagnóstico en pacientes con DLBCL. Material y Métodos Se revisó información de 171 pacientes con DLBCL tratados con inmuno-quimioterapia basada en rituximab en dos centros de referencia públicos de Montevideo, Uruguay. Las variables de resultado fueron la sobrevida global y libre de recaída. Resultados El recuento absoluto de monocitos, tratado como una variable dicotómica, predijo la sobrevida libre de recaída en pacientes de bajo riesgo, de acuerdo al puntaje R-IPI. El pronóstico fue peor en pacientes con altos recuentos al momento del diagnóstico. Conclusiones El recuento absoluto de monocitos puede identificar pacientes de alto riesgo, clasificados como de bajo riesgo por los puntajes tradicionales.


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Adulto Jovem , Monócitos , Linfoma Difuso de Grandes Células B/sangue , Contagem de Leucócitos , Prognóstico , Protocolos de Quimioterapia Combinada Antineoplásica , Estudos Retrospectivos , Linfoma Difuso de Grandes Células B/tratamento farmacológico , Imunoterapia
4.
Med. UIS ; 32(1): 33-37, ene.-jun. 2019. graf
Artigo em Espanhol | LILACS | ID: biblio-1040393

RESUMO

Resumen La apendicitis aguda en pediatría ocurre generalmente en escolares y adolescentes, siendo su principal complicación el absceso intraabdominal. Por su parte, la nefronía lobar aguda es una infección localizada del parénquima renal, de la cual no existen casos reportados de ésta como secundaria a apendicitis no perforada. Se presenta el caso de una preadolescente, quien seis días después de una apendicectomía consulta por dolor abdominal, vómito y fiebre. Ingresa con signos de respuesta inflamatoria sistémica, por lo que se inicia terapia antibiótica, y luego de tres días sin mejoría clínica, se realiza una ecografía abdominal que evidencia una lesión renal derecha sugestiva de nefronía lobar aguda y un absceso hepático del segmento VI y VII. Se inicia terapia antibiótica de amplio espectro con adecuada respuesta clínica. La nefronía lobar aguda debe tenerse en cuenta entre las complicaciones de la apendicitis, dado su comportamiento agresivo, rápida progresión a sepsis y frecuente asociación a cicatrices renales. MÉD.UIS.2019;32(1):33-7.


Abstract Acute appendicitis in pediatrics presented in scholar and adolescent ages have as its main complication an intraabdominal abscess. Moreover, acute lobar nephronia is a localized infection in the renal parenchyma. There are no cases reported about nephronia as a consequence of acute non-perforated appendicitis. This case describes a preadolescent presenting abdominal pain, vomit and fever, six days after acute appendicitis. She was admitted with signs of systemic inflammatory response syndrome, so antibiotic therapy was started. After three days there was no clinical improvement, whereby an abdominal ultrasound was performed, which reported injury in the right kidney suggestive of acute lobar nephronia and an hepatic abscess of VI and VII segments. Broad spectrum of antibiotic therapy was started with adequate clinic response. Acute lobar nephronia should be considered when studying acute appendicitis complications, given it's aggressive behavior, accelerated progression to sepsis and frequent association with renal scarring. MÉD.UIS.2019;32(1):33-7.


Assuntos
Humanos , Feminino , Criança , Nefrite , Pediatria , Apendicectomia , Complicações Pós-Operatórias , Infecções Intra-Abdominais
5.
Rev Med Chil ; 147(12): 1553-1560, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32186619

RESUMO

Background Prognosis of patients with Diffuse Large B Cell Lymphoma (DLBCL) is highly variable, and despite the use of modern immunochemotherapy regimens, almost 50% of patients will eventually relapse. Standard risk models, like the International Prognostic Index or the Revised International Prognostic Index (R_IPI) incorporate patient and tumor characteristics but do not consider variables related to host adaptive immunity which have been shown to be of significant prognostic value in non-Hodgkin lymphomas. Aim To analyze the prognostic significance of the absolute monocyte count at diagnosis in diffuse large-B-cell lymphoma in a retrospective setting. Material and Methods We reviewed data of 171 patients with DLBCL treated with Rituximab-based immunochemotherapy at two reference public Hospitals in Montevideo-Uruguay. The outcome measures were overall and relapse free survival. Results The absolute monocyte count, analyzed as a dichotomized variable predicted progression-free and overall survival in low risk patients according to the R-IPI score. Worse outcomes were observed in those with high monocyte count al diagnosis. Conclusions Absolute monocyte count could help in the identification of high-risk patients otherwise expected to have a good prognosis according to traditional scores.


Assuntos
Contagem de Leucócitos , Linfoma Difuso de Grandes Células B/sangue , Monócitos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Protocolos de Quimioterapia Combinada Antineoplásica , Feminino , Humanos , Imunoterapia , Linfoma Difuso de Grandes Células B/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Retrospectivos , Adulto Jovem
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